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. Author manuscript; available in PMC: 2016 Sep 2.
Published in final edited form as: Expert Opin Pharmacother. 2015 Sep 2;16(14):2095–2099. doi: 10.1517/14656566.2015.1083975

Figure 1. Brincidofovir (BCV) decreases adenovirus type 5 (Ad5)-induced lesions in the liver.

Figure 1

Syrian hamsters were immunosuppressed using cyclophosphamide, then infected intravenously with 1.9 × 1012 virus particles/kg of Ad5. Livers of hamsters sacrificed at day 6 were subjected to histopathological and immunohistochemistry (IHC) evaluation. Animals infected with Ad5 and not treated with BCV exhibited extensive coagulation necrosis throughout the liver (A) and widespread replication of Ad5, demonstrated by staining for the AdV fiber protein (B). Treatment of Ad5-infected hamsters with BCV resulted in a significant reduction in hepatocellular injury (C) and greatly reduced IHC staining for fiber (D). The arrows indicate intranuclear inclusion bodies. The scale bars represent 200 mm for the larger pictures and 50 mm for the insets. N, necrosis. (Reproduced from [12] Copyright 2007 National Academy of Sciences U.S.A.)