Figure 2. Plasma adenovirus (AdV) levels prior to (day +132 posttransplant) and during (day +133) treatment with brincidofovir (BCV).

AdV was first detected day +89 posttransplant, with a continued rise in AdV load despite administration of intravenous cidofovir days +92 to +132 posttransplant and intravenous immunoglobulin (IVIG) (day +129 posttransplant). Treatment with BCV was initiated on day +133 posttransplant at 2 mg/kg administered twice weekly increasing to 3 mg/kg after the sixth dose. After the virus became undetectable (less than 10¹² copies/mL) (day +159 posttransplant), administration of BCV continued at 3 mg/kg but the schedule was reduced to once weekly for maintenance. Arrows indicate timing of 1st, 10th, and 20th BCV doses. (Reproduced with permission from [14])