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. 2016 May 13;11(5):e0155645. doi: 10.1371/journal.pone.0155645

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© 2016 Gómez-SanMiguel et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 2 — Effect of D-Trp(8)-γMSH (γMSH) (500 μg/kg i.p.) administration on hypothalamic mRNA expression of: IL-1β (A), COX-2 (B) and CRH (C), and on serum concentrations of ACTH (D) and corticosterone (E) in control (C) and in LPS-injected (250 μg/kg) rats. PF = pair-fed rats. Each bar represents the mean ± SE for n = 7–10. mRNA expression was quantified using real-time RT-PCR and is presented as the increase of the mean value in control rats treated with saline. LPS injection increased hypothalamic IL-1β, COX-2 and CRH mRNA levels as well as serum ACTH and corticosterone levels (P<0.01) in rats injected with saline, but not in rats injected with γMSH. *P< 0.05 and **P< 0.01, vs. their respective control group. +P<0.05, ++P<0.01 vs. LPS-saline, °°P<0.01 vs. PF. LSD multiple comparison test, following one-way ANOVA.