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. 2016 May 13;12(5):e1004935. doi: 10.1371/journal.pcbi.1004935

Fig 1. Transcriptional activation via the Mediator complex.

Fig 1

The schematic diagram shows the gene-specific transcription factor GCN4 bound sequence-specifically to a target site ("Upstream Activation Site"; "UAS"). The basal transcriptional machinery (including RNA polymerase II [RNAPII]; basal transcription factors TFIIB, TFIID, TFIIE, TFIIF and TFIIH; the multi-subunit "Mediator Complex") assembles around the transcription start site indicated by an arrow. The GAL11 subunit of the Mediator is specifically identified. The regulatory protein-protein interaction of the GCN4-activation domain (cAD) with GAL11 is represented by a two-headed arrow.