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. 2016 May 6;11:1959–1971. doi: 10.2147/IJN.S99945

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© 2016 Bai et al. This work is published and licensed by Dove Medical Press Limited

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The expression of miR34a and Bcl-2 in BEAS-2B cells exposed to TNPs for 24 hours.

Notes: RNA was extracted and expression of gene was detected by real-time PCR. U6 and β-actin were utilized for an endogenous reference to standardize miRNA and mRNA expression levels. The protein level of Bcl-2 was measured by Western blot. TNPs downregulated the expression of miR34a (A) and the expression of Bcl-2 was decreased both in mRNA and protein levels (B–D) in a dose-dependent manner. *P<0.05, compared with control. Data are expressed as mean ± SD; n=3.

Abbreviations: Bcl-2, B-cell lymphoma/leukemia-2; miR34a, microRNA 34a; miRNA, microRNA; mRNA, messenger RNA; SD, standard deviation; TNPs, titanium dioxide nanoparticles.