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. 2016 May 13;12(5):e1006056. doi: 10.1371/journal.pgen.1006056

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© 2016 Vanderperre et al

This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Fig 4 — (A) Genotypes frequencies of embryos derived from heterozygous MPC1^gt/+ timed breeding (from E10.5 to E15.5). (B) Proportion of live and dead MPC1^gt/gt embryos (relative to total embryos) from E10.5 to E15.5. (C) Morphology of MPC1^gt/gt E13.5 embryos is normal compared to MPC1^+/+ and MPC1^gt/+ littermates. Scale bar: 1mm. (D) Hematoxylin and eosin (H&E) staining of paraffin-embedded E13.5 embryo sections. Insets reveal lesions (arrowheads) in the pons region of the brain stem in MPC1^gt/gt embryos.