Table 4.
Brain MRI acquisition parameters
| Sequence | Spatial resolution | TR (ms) | TE (ms) | Slices | R | Flip Angle | Additional Details | Outcome Measure | |
|---|---|---|---|---|---|---|---|---|---|
| T1-weighted | fast field echo | 1×1×1 mm3 | 8.9 | 4.6 | 170 | 2 | 5° | – | Cortical thickness, gray matter ROIs |
| T2-weighted FLAIR | turbo spin echo inversion recovery | 0.45×0.45×4 mm3 | 11000 | 121 | 24 | 1.75 | 90° | – | WMH volume |
| SWI | fast field echo | 0.75×0.75×1.5 mm3 | 40 | 34 | 80 | 2 | 20° | – | Number and location of microhemorrhages |
| DTI | spin echo echo-planar imagine | 2×2×2 mm3 | 10000 | 60 | – | 2 | 90° | Δ = 28.9 ms, δ = 12.6 ms, 31 directions | FA, MD, RD, and AD |
| VE-pCASL | single-shot gradient echo-planar imaging | 3×3×7 mm3 | 3900 | 13 | 17 | 2 | – | labeling duration = 1650 ms, post-labeling delay = 1525 ms, Hanning-windowed labeling pulse train (pulse duration = 0.7 ms) | CBF, CVR |
| MRA | gradient echo | 0.35×0.35×0.50 mm3 | 6.8 | 3.8 | 150 | 2 | 12° | – | CoW variants |
| VWI | Noncontrasted 3D turbo-spin-echo anti-DRIVE | 0.6 × 0.6 × 1 mm3 | 1500 | 38.5 | 90 | 1.5 | 90° | – | ICA, MCA, ACA, and VB wall thickness |
FLAIR, fluid attenuated inversion recovery; SWI, susceptibility weighted imaging; DTI, diffusion tensor imaging; VE-pCASL, vessel-encoded pseudo-continuous arterial spin labeling; CBF, cerebral blood flow; CVR, cerebrovascular reactivity; MRA, magnetic resonance angiography; CoW, circle of Willis; VWI, vessel wall imaging; R, SENSE factor; ROIs, regions of interest; WMH, white matter hyperintensities; ICA, internal carotid artery; MCA, middle cerebral artery; ACA, anterior cerebral artery; VB, vertebrobasilar; FA, fractional anisotropy; MD, mean diffusivity; RD, radial diffusivity; AD, axial diffusivity.