Table 1.
Mouse | Age (wks) | ZIKV Strain (Dakar) | Dose (FFU) | Route | # infected | % Survival |
---|---|---|---|---|---|---|
WT | 4 | 41519 | 1 x 103 | SCa | 5 | 100 |
WT | 4 | 41667 | 1 x 103 | SC | 5 | 100 |
WT | 4 | 41671 | 1 x 103 | SC | 5 | 100 |
WT | 1 | 41519 | 1 x 104 | IPb | 15 | 67 |
CD-1 | 4 | 41519 | 1 x 103 | SC | 5 | 100 |
CD-1 | 4 | 41667 | 1 x 103 | SC | 5 | 100 |
CD-1 | 4 | 41671 | 1 x 103 | SC | 5 | 100 |
AG129 | 4 | 41519 | 1 x 104 | SC | 5 | 0 |
Ifnar1−/− | 4 | 41519 | 1 x 103 | SC | 3 | 0 |
Ifnar1−/− | 4 | 41667 | 1 x 103 | SC | 2 | 0 |
Ifnar1−/− | 4 | 41671 | 1 x 103 | SC | 2 | 0 |
Mavs−/− | 7 | 41519 | 1 x 104 | SC | 8 | 100 |
Ifnlr1−/− | 4 | 41519 | 1 x 104 | SC | 5 | 100 |
Irf3−/− | 8 | 41519 | 1 x 104 | IP | 4 | 100 |
Irf3−/− | 8 | 41519 | 1 x 104 | SC | 4 | 100 |
Irf5−/− | 4 | 41519 | 1 x 104 | IP | 5 | 100 |
Irf5−/− | 4 | 41519 | 5 x 104 | IP | 2 | 100 |
Irf5−/− | 4 | 41519 | 1 x 104 | SC | 5 | 100 |
Irf5−/− | 4 | 41519 | 1 x 104 | SC | 3 | 100 |
Irf5−/− | 4 | 41519 | 1 x 103 | SC | 5 | 100 |
Irf5−/− | 4 | 41667 | 1 x 103 | SC | 5 | 100 |
Irf5−/− | 4 | 41671 | 1 x 103 | SC | 5 | 100 |
Ifit1−/− | 4 | 41519 | 1 x 104 | SC | 5 | 100 |
Ifit2−/− | 4 | 41519 | 1 x 104 | SC | 5 | 100 |
Ifitm3−/− | 4 | 41519 | 1 x 104 | SC | 3 | 100 |
Isg15−/− | 4 | 41519 | 1 x 104 | SC | 4 | 100 |
Isg15−/− | 6 | 41519 | 1 x 104 | SC | 10 | 100 |
Ube1l−/− | 4 | 41519 | 1 x 104 | SC | 5 | 100 |
Mb21d1−/− (cGas) | 4 | 41519 | 1 x 104 | SC | 5 | 100 |
Mb21d1−/− x Tmem173−/− DKO | 4 | 41519 | 1 x 104 | SC | 3 | 100 |
Tmem173−/− (STING) | 4 | 41519 | 1 x 104 | SC | 5 | 100 |
Subcutaneous route of inoculation,
Intraperitoneal route of inoculation