Table 4: Calendar period of treatment in relation to insufficient cardiac monitoring and cardiotoxicity in patients with breast cancer who underwent treatment with adjuvant trastuzumab in Ontario from 2003 to 2009 (n = 3777).
| Outcome | Calendar period, OR (95% CI) | |
|---|---|---|
| 2003-2007 | 2008-2009 | |
| Insufficient monitoring | ||
| Model 1* | 1 (Reference) | 0.93 (0.74 to 1.16) |
| Cardiotoxicity | ||
| Model 1* | 1 (Reference) | 0.56 (0.45 to 0.70) |
| Model 2† | 1 (Reference) | 0.54 (0.42 to 0.69) |
Note: OR = odds ratio.
*Model 1 was adjusted for age, Charlson Deyo index, previous heart failure, hypertension, previous myocardial infarction, diabetes mellitus, income, rural residence, annual hospital volume, cumulative physician volume, hospital clustering, physician clustering and Local Health Integration Network clustering.
†Model 2 was adjusted for all variables in model 1 and further adjusted for sufficiency of cardiac monitoring.