Skip to main content
. Author manuscript; available in PMC: 2016 May 13.
Published in final edited form as: Cancer Discov. 2012 Feb 28;2(3):260–269. doi: 10.1158/2159-8290.CD-11-0242

Figure 3. nab-paclitaxel promotes elevated intratumoral gemcitabine levels.

Figure 3

A) The dFdC:dFdU ratio in bulk tumor was quantified in mice 2 hours after the last dose of gemcitabine. (n≥12) B) Intratumoral levels of dFdCTP were measured in duplicate samples from mice in each cohort 2 hours after the last dose of gemcitabine. (n≥12) C) Intratumoral levels of paclitaxel were measured in samples from mice in each cohort 4 hours after the last dose of nab-paclitaxel. (n≥7) D) 2 KPC cell lines were pre-treated with 10μM paclitaxel or DMSO for 36 hours or 10μM THU (cytidine deaminase inhibitor) for 30 minutes as a positive control and incubated with 1μM gemcitabine for 2 hours. dFdCTP levels were then measured. Data is representative of three independent experiments.