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In vivo osteogenesis. (A) nHAC/PLA, (B) sham PDLSCs + nHAC/PLA, (C) OVX PDLSCs + nHAC/PLA, (D) OVX PDLSCs + nHAC/PLA + E2. Magnification, ×200, NB, newly formed bone. Black arrowheads indicate blood vessels, white arrowheads indicate osteoblastic cells. OVX, ovariectomized PDLSCs, periodontal ligament stem cells; nHAC/PLA, nano-hydroxyapatite/collagen/poly(L-lactide).
