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. 2016 May 13;3(2):ENEURO.0011-16.2016. doi: 10.1523/ENEURO.0011-16.2016

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Copyright © 2016 Marchenko et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International, which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Figure 7. — Perturbations of respiratory activity by pharmacologically disrupting of GABA_Aergic and glycinergic inhibition in the BötC of adult rat in vivo. A, Gabazine and strychnine cocktail (110 nl, 250 µm) slowly injected during time period indicated (by the brown bar at the top and blue rectangle), progressively reduced respiratory frequency leading to transient apnea in this example (∫PN, black trace, top). Changes in the inspiratory (T_I, red) and expiratory (T_E, blue) phase durations and respiratory frequency (f_R) are shown at the bottom; f_R was reduced mainly due to prolongation of T_E. B–E, Mean time series from the start of microinjection showing developing changes of normalized T_I (B, red curve), T_E (C, blue curve), f_R (D, green curve), and integrated PN activity amplitude (E, magenta curve) for a representative experimental group (n = 6). Solid colored curves are group mean time and normalized parameter values; gray bands are ±1 SEM for the mean normalized parameter values.