Table 1.

Series of MRSA isolates included in the study

Isolate	Specimen	Collection date	Time frame (days/weeks)^a				Ceftaroline MIC (mg/L)	PBP2a amino acid residue number			Clonal type^c
				Genome comparison^b				nPBD	PBD
				SNPs	InDels	total		nPBD	447	601
89	wound (wrist)	1/2/14	NA	NA	NA	NA	0.75/0.75/0.75	WT	Glu	Ala	ST5-II
91	wound (lumbar spine)	1/3/14	28/4	104	70	174	4/4/6	WT	Lys	Ser	ST5-II
86	blood (colony 1)	13/3/14	40/6	93	64	157	8/8/8	WT	Lys	Ser	ST5-II
88	blood (colony 2)	13/3/14	40/6	92	59	151	4/6/6	WT	Lys	Ser	ST5-II

nPBD, non-penicillin-binding domain.

^aPeriod after recovery of baseline MRSA isolate.

^bNumbers of SNPs, insertions and deletions (InDels) compared with baseline genome.

^cCombination of MLST (ST) type and SCCmec type. All isolates were spa type t002/TJMBMDMGMK (Ridom/Kreiswirth).