Table 14.2.

Antagonism of IL-1R1/TLR4 in rodent models of seizures

Seizure reduction in rodents exposed to an acute challenge
Kainic acid (lesional model), bicuculline and febrile seizures (non lesional models) [28, 87, 114, 119]
Status epilepticus [24, 64]
Electrical rapid kindling [88, 5, 6]
Chronic recurrent seizures reduced in
mTLE mouse model [66, 67]
SWD in GAERS & WAG/Rij (absence seizures models) [1, 49]
Other inflammatory signaling contributing to seizures are mediated by
TNF-α, IL-6, COX-2 & complement system (reviewed in [50, 115, 3])