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. Author manuscript; available in PMC: 2016 May 14.
Published in final edited form as: Curr Biol. 2009 Dec 29;19(24):R1126–R1132. doi: 10.1016/j.cub.2009.10.067

Figure 2. Chromatid capture.

Figure 2

(A) Current models suggest that Smc1/3 subunit interactions are dynamic: either hinge dimerization domains or ATPase globular head domains may transiently let go. DNA is then thought to enter the exposed lumen, becoming trapped upon reformation of Smc1/3 subunit interactions. Other models of cohesin association with chromatin (lateral binding, filamentous or spiraled structures) are not shown. DNA is depicted in a ‘naked’ state — note that a single 30 nm compacted chromatin fiber would completely fill the proposed lumen and distort the coiled-coil domains of the Smc1/3 complex (not shown). (B) Cohesin deposition and chromatid capture may be coupled to DNA replication. Deposition factors Scc2 and Scc4 are not shown; leading and lagging replisome complexes are simplified to a large hexagon.