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. 2016 Apr 13;183(10):884–893. doi: 10.1093/aje/kwv226

Table 6.

Potential Mediation of Racial/Ethnic Disparities Among Women Diagnosed with ER/PR-Negative Breast Cancer, Breast Cancer Care in Chicago Study, 2005–2008

Characteristic No. of Women Average Controlled Direct Associations
Rescaled Coefficients
RDa 95% CIb % Reductionc % Reductiond P Valuee
Minority Women Versus Non-Hispanic White Women
Age (baseline model) 746 0.133 0.081, 0.191
Modeled separately
 SEP 746 0.072 −0.020, 0.145 46
 RPF 746 0.091 0.032, 0.161 32
Modeled together 746 0.053 −0.039, 0.125 60 61 0.002
 SEP 35
 RPF 26
Non-Hispanic Black Women Versus Non-Hispanic White Women
Age (baseline model) 603 0.163 0.100, 0.225
Modeled separately
 SEP 603 0.102 0.008, 0.193 37
 RPF 603 0.122 0.050, 0.193 25
Modeled together 603 0.087 −0.010, 0.189 47 46 0.002
 SEP 26
 RPF 20
Hispanic Women Versus Non-Hispanic White Women
Age (baseline model) 443 0.075 −0.004, 0.150
Modeled separately
 SEP 443 0.001 −0.091, 0.097 99
 RPF 443 0.040 −0.030, 0.112 47
Modeled together 443 −0.013 −0.095, 0.091 117 119 0.007
 SEP 82
 RPF 36

Abbreviations: CI, confidence interval; ER, estrogen receptor; PR, progesterone receptor; RD, risk difference; RPF, reproductive factors; SEP, socioeconomic position.

a RD calculated using logistic regression with marginal standardization.

b 95% CI calculated using bias-corrected bootstrap methods.

c Percent reduction in the risk difference when compared with the baseline model.

d Percent reduction based on the method of rescaled coefficients.

e P value from a test of the difference in coefficients between the reduced model (without the mediators) and the full model (which included the mediators).