Table 1.
Subject Demographics and Cognitive Task Data
| Demographics
|
CTRL (n= 12)
|
PD-NON (n=13)
|
PD-FOG (n= 13)
|
|---|---|---|---|
| Age (yr) | 72.3 ± 5.28 | 68.1 ± 7.04 | 68.7 ± 5.84 |
| Sex (# male) | 4 | 5 | 7 |
| MOCA | 26.4 ± 2.43 | 26.3 ± 2.78 | 25.6 ± 2.18 |
| Years since diagnosis | 4.73 ± 3.93 | 8.73 ± 5.93 | |
| LEDD (mg) | 691 ± 734 | 1043 ± 684 | |
| MDS-UPDRS-I | 7.23 ± 3.00 | 13.2 ± 7.06* | |
| MDS-UPDRS-II | 8.08 ± 5.35 | 11.9 ± 5.09 | |
| MDS-UPDRS-III | 36.3 ± 13.3 | 40.4 ± 7.72 | |
| NFOGQ | 10.9 ± 5.54 | ||
| a Anti-saccade error rate (%) | 15.8 ± 18.6 | 34.6 ± 37.8^ | 25.4 ± 42.6 |
|
Cognitive Tasks
|
|||
| a GNG RT (ms) | 400.0 ± 44.0 | 414.0 ± 43.5 | 392.0 ± 70.5 |
| GNG False Alarm (%) | 4.33 ± 3.86 | 3.49 ± 2.08 | 3.90 ± 2.69 |
| GNG Misses (%) | 0.72 ± 1.15 | 0.46 ± 0.69 | 1.23 ± 0.64 |
| TMT B-A Completion Time (s) | 46.4 ± 20.7 | 45.9 ± 19.7 | 68.6 ± 47.1 |
Values represent Mean ± SD;
a
Median ± IQR. MOCA: Montreal Cognitive Assessment; LEDD: Levodopa equivalent daily dose; MDS-UPRDS: Movement Disorder Society Unified Parkinson Disease Rating Scale I (Non-motor) II (Motor Aspects of Daily Living III (Motor Assessment), NFOGQ: New Freezing of Gait Questionnaire; GNG: Go-NoGo; RT: Reaction Time; TMT: Trail-making task.
*
Significantly greater than PD-NON (p<0.05);
^
Significantly greater than CTRL (p<0.05)