Table 2.
Summary of variants from the Axiom® miRNA Target Site Genotyping Array with the most statistically significant associations from age, sex, and PC 1-2 adjusted logistic regression models. A1 miRNA and A2 miRNA refer to miRNAs predicted to bind in the presence of each alternative allele. AIM = ancestry informative marker. GWAS = GWAS compatibility marker. NA = no prediction found. Grey indicates the availability of high-throughput genotype data and gene expression data for the nearest gene.
| rsID | CHR | BP | A1a | MAF | OR | SEb | P | Gene | A1 miRNA | A2 miRNA |
|---|---|---|---|---|---|---|---|---|---|---|
| rs2985 | 6 | 34845648 | C | 0.30 | 0.66 | 0.10 | 3.7E-05 | UHRF1BP1 (intron) | miR-4529-5p | miR-885-5p |
| rs1139139 | 10 | 5020625 | T | 0.27 | 1.54 | 0.11 | 6.0E-05 | AKR1C1 (downstream) | NA | miR-451b miR-556-5p |
| rs6827968 | 4 | 161399652 | A | 0.34 | 1.48 | 0.10 | 1.0E-04 |
RAPGEF2 (downstream) FSTL5 (downstream) |
AIM | AIM |
| rs12130051 | 1 | 19545053 | T | 0.06 | 2.27 | 0.21 | 1.2E-04 | KIAA0090 (3'-UTR) | NA | miR-222 miR-1244 miR-3129 |
| rs80350662 | 1 | 178819064 | A | 0.04 | 2.63 | 0.26 | 2.1E-04 | RALGPS2 (intron) | miR-32-3p miR-4775 |
miR-1277-5p miR-889 |
| rs1834481 | 11 | 112023827 | G | 0.12 | 0.60 | 0.14 | 2.4E-04 | IL18 (intron) | NA | miR-637 miR-5009-5p miR-541-3p |
| rs1044724 | 6 | 125412231 | C | 0.08 | 0.54 | 0.17 | 2.5E-04 |
RNF217 (downstream) TPD52L1 (upstream) |
miR-3978 | miR-3978 |
| rs4766991 | 12 | 113137384 | T | 0.16 | 1.58 | 0.13 | 2.7E-04 |
PTPN11 (downstream) RPH3A (upstream) |
In promoter for miR-1302-1 | In promoter for miR-1302-1 |
| rs7746892 | 6 | 125408263 | G | 0.08 | 0.54 | 0.17 | 2.9E-04 |
RNF217 (downstream) TPD52L1 (upstream) |
miR-545 | miR-1252 miR-4476 miR-4533 miR-873 |
| rs7746860 | 6 | 125408221 | G | 0.08 | 0.54 | 0.17 | 2.9E-04 |
RNF217 (downstream) TPD52L1 (upstream) |
miR-2681 | miR-1295 miR-4747-3p |
| rs2489495 | 10 | 38502333 | T | 0.20 | 0.66 | 0.12 | 3.6E-04 | LOC1001290 55 (exon) | miR-635 | NA |
| rs853158 | 5 | 142605172 | C | 0.36 | 0.71 | 0.10 | 3.7E-04 | ARHGAP26 (3'-UTR) | miR-3926 | miR-4480 |
| rs9374072 | 6 | 109591586 | G | 0.31 | 0.71 | 0.10 | 3.7E-04 |
CEP57L1 (downstream) CCDC162 (upstream) |
miR-605 | NA |
| rs471429 | 6 | 125409031 | G | 0.09 | 0.57 | 0.16 | 3.9E-04 |
RNF217 (downstream) TPD52L1 (upstream) |
miR-3126-5p miR-3174 miR-3591-5p miR-3606 miR-4419a miR-4510 miR-921 |
miR-4270 miR-4441 |
| rs12268559 | 10 | 32856746 | C | 0.07 | 0.54 | 0.18 | 4.3E-04 | CCDC7 (coding) | miR-578 | NA |
| rs142004998 | 23 | 119760042 | C | 0.08 | 0.51 | 0.19 | 4.4E-04 | C1GALT1C1 (3'-UTR) | miR-1284 miR-337-3p miR-520d-5p |
NA |
| rs3180466 | 2 | 129023866 | G | 0.03 | 0.38 | 0.28 | 4.5E-04 | HS6ST1 (3'-UTR) | miR-4758-5p miR-574-5p miR-615-3p miR-1238-5p miR-4745-5p miR-3677-5p |
miR-4669 miR-3659 |
| rs79029362 | 1 | 178516408 | G | 0.03 | 2.91 | 0.30 | 4.6E-04 | C1orf220 (exon) | miR-455-3p | NA |
| rs4766992 | 12 | 113137531 | A | 0.26 | 1.45 | 0.11 | 4.7E-04 |
PTPN11 (downstream) RPH3A (upstream) |
Upstream of miR-1302- encoding gene | Upstream of miR-1302-encoding gene |
| rs56391924 | 10 | 32745248 | C | 0.07 | 0.54 | 0.18 | 4.7E-04 | CCDC7 (missense) | miR-4273 | NA |
| rs117299563 | 19 | 52095600 | C | 0.02 | 0.28 | 0.37 | 4.9E-04 | FLJ30403 (exon,3'-UTR) | NA | miR-3684 |
| rs6072275 | 20 | 39743905 | A | 0.15 | 1.59 | 0.13 | 4.9E-04 | TOP1 (intron) | GWAS | NA |
| rs107321 | 22 | 18512282 | T | 0.41 | 0.72 | 0.09 | 4.9E-04 | FLJ41941 (exon) | miR-1284 miR-337-3p miR-374a-5p |
NA |
| rs1972820 | 2 | 212243422 | G | 0.36 | 1.41 | 0.10 | 4.9E-04 | ERBB4 (3'-UTR) | miR-4633-5p miR-532-5p |
miR-3144-3p miR-875-5p |
| rs12247495 | 10 | 32802829 | C | 0.07 | 0.54 | 0.18 | 4.9E-04 | CCDC7 (intron) | miR-539-5p | NA |
a
A1 = effect allele for the corresponding odds ratios;
b
SE = standard error of the beta estimate