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. Author manuscript; available in PMC: 2017 Jun 1.
Published in final edited form as: Semin Cell Dev Biol. 2016 Feb 6;54:28–41. doi: 10.1016/j.semcdb.2016.02.009

Figure 1. Activities of STAT3 that contribute to the multi-organ, systemic response to tumor.

Figure 1

Activating roles of STAT3 are shown in orange, with the inhibitory role of STAT3 on cardiac hypotrophy shown in blue. Cachexia-promoting effects of organ dysfunction are shown in orange. Genetically confirmed activities of STAT3 in cachexia models are shown in boldface; activities implicated, but not functionally confirmed in cancer cachexia are shown in italics.