Table 2.

Effect of Notch2 knockdown and/or WA treatment on plasma cytokine levels from the MDA-MB-231 xenograft study.

	Group
Cytokine	Control sh-Veh (n = 5) Mean (95% CI), pg/mL	Notch2 sh-Veh (n = 5) Mean (95% CI), pg/mL	Notch2 sh-WA (n = 6) Mean (95% CI), pg/mL	P
FGF-2	52.34 (−10.94 to 115.60)	116.40 (28.97 to 203.90)	174.30 (−6.56 to 355.20)
G-CSF	2.63 (−4.67 to 9.92)	100.70 (22.14 to 179.30)	15.88 (−10.22 to 41.97)	0.004 (†), 0.009 (‡)
GM-CSF	78.24 (−27.50 to 184.00)	441.10 (46.83 to 835.40)	102.40 (32.14 to 172.70)	0.03 (†), 0.03 (‡)
GRO	200.70 (−140.40 to 541.90)	899.40 (208.40 to 1590.00)	259.40 (−29.35 to 548.10)	0.04 (†), 0.0495 (‡)
IFN-γ	14.75 (3.27 to 26.23)	17.03 (3.80 to 30.27)	21.71 (12.07 to 31.34)
IL-6	16.67 (−12.41 to 45.75)	134.80 (17.83 to 251.80)	24.90 (2.16 to 47.64)	0.02 (†), 0.02 (‡)
IL-8	207.20 (−41.72 to 456.10)	1465.00 (190.80 to 2740.00)	328.00 (20.36 to 635.60)	0.02 (†), 0.03 (‡)
IL-15	2.88 (−5.11 to 10.87)	36.37 (−1.90 to 74.64)	6.16 (−5.40 to 17.72)	0.04 (†)
IL-17	29.25 (21.67 to 36.83)	39.29 (15.73 to 62.84)	47.50 (40.32 to 54.68)
IP-10	7.85 (−3.36 to 19.05)	21.53 (−0.01 to 43.08)	1.92 (−1.36 to 5.19)	0.03 (‡)
MDC (CCL22)	53.76 (38.37 to 69.15)	78.26 (43.43 to 113.10)	61.07 (34.63 to 87.51)
sCD40L	5.71 (−10.15 to 21.57)	16.71 (−11.61 to 45.03)	38.60 (−60.63 to 137.80)
TNF-α	0.58 (−.68 to 1.84)	1.00 (−0.48 to 2.48)	0.02 (−0.03 to 0.07)
VEGF	0.00 (0.00 to 0.00)	11.36 (−15.97 to 38.68)	6.57 (−10.32 to 23.47)

^†Statistically significant between Control sh-Veh and Notch2 sh-Veh.

^‡Statistically significant between Notch2 sh-Veh and Notch2 sh-WA.