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Inhibitory effects of 13’-COOHs and tocopherols on COX-2 and 5-LOX
| IC50 (μM) | δT-13’-COOH | δTE-13’-COOH | γT | δT |
|---|---|---|---|---|
| COX-2 | 4 ± 1 | 9.8 ± 2 | > 50 | > 50 |
| 5-LOX | 2 ± 0.5 | 1 ± 0.5 | > 50 | > 50 |
The effect of 13’-COOHs or tocopherols on COX-2 and 5-LOX were evaluated with purified human enzymes as described in Materials and Methods. Results are mean ± SEM based on four or more independent experiments.
