Table 2.
Changes in normalized blood flow, blood volume, and permeability. Estimated change per day significance for changes in normalized values of blood flow, blood volume, and permeability in whole tumors, tumor center, tumor periphery, and normal brain tissue based on linear mixed effect models. Blood flow in the whole tumor and tumor center, blood volume, and permeability surface of the whole tumor declined over time
| Tissue | Normalized Perfusion Values | |||||
|---|---|---|---|---|---|---|
| Blood Flow (mL/100 g/min) | FDR (P) | Blood Volume (mL/100 g) | FDR (P) | Permeability (mL/100 g/min) | FDR (P) | |
| Whole tumor | −0.006 | *0.009 (.004) | −0.009 | *0.005 (.001) | −0.058 | *0.009 (.004) |
| Tumor center | −0.008 | *0.005 (.001) | −0.010 | *0.009 (.005) | −0.069 | 0.104 (.081) |
| Tumor periphery | −0.004 | 0.20 (.20) | −0.007 | 0.027 (.018) | −0.056 | 0.13 (.11) |
A significant difference is noted by an asterisk.
FDR, false discovery rate.