Table 1.
Characteristics of all donors, and domestic donors only, where a donation occurred, by randomized product
| All Donors | Domestic Donors | |||||
|---|---|---|---|---|---|---|
| PBSC | Bone Marrow | PBSC | Bone Marrow | |||
| Variable | N (%) | N (%) | p-valuea | N (%) | N (%) | p-valuea |
| Number of donors | 262 | 264 | 182 | 190 | ||
| Donated non-randomized product | 1 | 11 | 1 | 8 | ||
| Timing of donation | ||||||
| First | 255 | 254 | 175 | 180 | ||
| Second | 7 | 10 | 7 | 10 | ||
| Number of donor centers | 44 | 47 | 42 | 45 | ||
| Number of apheresis centers | 55 | 8 | 53 | 7 | ||
| Number of collection centers | 1 | 50 | 1 | 48 | ||
| Donor sex | 0.077 | 0.107 | ||||
| Female | 88 (34) | 70 (27) | 69 (38) | 57 (30) | ||
| Male | 174 (66) | 194 (73) | 113 (62) | 133 (70) | ||
| Donor age at donation, years | 0.058 | 0.076 | ||||
| 18 to 29 | 99 (38) | 111 (42) | 65 (36) | 71 (37) | ||
| 30 to 44 | 115 (44) | 124 (47) | 76 (42) | 93 (49) | ||
| 45 or older | 48 (18) | 29 (11) | 41 (23) | 26 (14) | ||
| Median (Range) | 34 (19–60) | 33 (19–61) | 0.097 | 34 (19–60) | 34 (19–61) | 0.297 |
| Donor race | 0.375b,c | 0.368b,c | ||||
| Caucasian | 230 (88) | 224 (85) | 151 (83) | 150 (80) | ||
| Hispanic | 11 (4) | 12 (5) | 10 (6) | 12 (6) | ||
| Black/African American | 7 (3) | 8 (3) | 7 (4) | 8 (4) | ||
| Asian/Pacific Islander | 4 (2) | 4 (2) | 4 (2) | 4 (2) | ||
| American Indian/Alaska Native | 2 (1) | 2 (1) | 2 (1) | 2 (1) | ||
| Other/Multiple Race | 7 (3) | 12 (5) | 7 (4) | 12 (6) | ||
| Decline/Unknown | 1 NA | 2 NA | 1 N/A | 2 N/A | ||
| Donor BMI, kg/m2 | 0.303b,d | 0.365b,d | ||||
| Underweight (<18.5) | 3 (1) | 0 | 2 (1) | 0 | ||
| Normal (18.5–24.9) | 99 (38) | 86 (33) | 59 (32) | 52 (27) | ||
| Overweight (25–29.9) | 85 (32) | 98 (37) | 56 (31) | 69 (36) | ||
| Obese (30+) | 75 (29) | 79 (30) | 65 (36) | 69 (36) | ||
| Unknown | 0 N/A | 1 N/A | 0 N/A | 0 N/A | ||
| Median (Range) | 26.8 (17.8–44.9) | 27.0 (18.9–48.5) | 0.235 | 27.6 (17.8–44.9) | 27.9 (19.0–48.5) | 0.312 |
| Donor weight, kg | ||||||
| Median (Range) | 82 (47–142) | 85 (54–144) | 0.053 | 85 (47–142) | 87 (55–144) | 0.066 |
| Donor cytomegalovirus | 0.508b | |||||
| Nonreactive | 175 (68) | 184 (71) | 116 (64) | 127 (67) | ||
| Reactive | 81 (32) | 75 (29) | 66 (36) | 63 (33) | 0.529 | |
| Unknown | 6 N/A | 5 N/A | 0 N/A | 0 N/A | ||
| Year of donation | 0.608 | 0.909 | ||||
| 2004 | 16 (6) | 14 (5) | 16 (9) | 14 (7) | ||
| 2005 | 36 (14) | 44 (17) | 34 (19) | 42 (22) | ||
| 2006 | 50 (19) | 47 (18) | 37 (20) | 32 (17) | ||
| 2007 | 70 (27) | 70 (27) | 48 (26) | 53 (28) | ||
| 2008 | 62 (24) | 51 (19) | 31 (17) | 31 (16) | ||
| 2009 | 28 (11) | 38 (14) | 16 (9) | 18 (9) | ||
| Baseline WBC, ×109/L | ||||||
| Median (Range) | 6.6 (2.5–11.5) | 6.3 (2.8–12.8) | 0.062 | 6.6 (2.5–11.5) | 6.4 (2.8–12.8) | 0.098 |
| Baseline platelets, ×109/L | ||||||
| Median (Range) | 258 (153–409) | 249 (144–447) | 0.180 | 257 (153–409) | 248 (147–447) | 0.281 |
| Baseline hemoglobin-Male, g/dL | ||||||
| Median (Range) | 15.3 (9.3–17.1) | 15.2 (12.8–17.8) | 0.753 | 15.4 (11.0–17.1) | 15.4 (12.8–17.8) | 0.881 |
| Baseline hemoglobin-Female, g/dL | ||||||
| Median (Range) | 13.4 (10.7–15.2) | 13.3 (11.4–15.4) | 0.950 | 13.5 (11.5–15.2) | 13.3 (11.5–15.4) | 0.746 |
| Baseline neutrophils, ×109/L | ||||||
| Median (Range) | 4.2 (1.3–7.8) | 4.0 (1.8–10.3) | 0.033 | 4.2 (1.3–7.5) | 4.0 (1.8–10.3) | 0.055 |
| Baseline mononuclear cells, ×109/L | ||||||
| Median (Range) | 2.3 (1.1–5.2) | 2.3 (0.7–4.7) | 0.227 | 2.3 (1.1–5.2) | 2.3 (0.7–4.3) | 0.150 |
Abbreviations: BMI = body mass index; PBSC = peripheral blood stem cells; N = number; N/A = not available; WBC = white blood cell
a
The Pearson chi-square test was used for comparing discrete variables; the Kruskal-Wallis test was used for comparing continuous variables.
b
Test performed excluding the donors in the unknown category
c
Test performed for Caucasian vs. Other
d
Test performed for Underweight/Normal vs. Overweight vs. Obese