. Author manuscript; available in PMC: 2016 May 15.

Published in final edited form as: J Neurooncol. 2015 Dec 5;127(1):1–13. doi: 10.1007/s11060-015-2018-4

Table 2.

T-Cell Proliferation Assays

Assay	Study	Phase	Immunological Outcome	Immunological Correlation with Clinical Outcome
[3H] Thymidine Incorporation	Vik-Mo EO, et al (2013)	I/II	7/7 patients with induced T-lymphocyte proliferation	-
[3H] Thymidine Incorporation	Sampson JH, et al (2009)	I	11/12 patients demonstrated increased proliferation to KLH;10/12 patients demonstrated increased proliferation to PEPvIII	-
DDPA	Fadul CE, et al (2011)	Pilot	Precursor frequency of CD4+ T cells increased post vaccination (p = 0.004); CD4+ and CD8+ IFNγ producing cells demonstrated trends towards post-vaccination increase (p = 0.016 and p = 0.105)	Increased CD4+ and CD8+ precursor frequency along with increased proliferating percentages of CD4+ and CD8+ IFNγ producing cells correlated with a trend towards increased PFS (p = 0.09) and significantly increased OS (p = 0.002) as elements of hierarchical clustering analysis
DDPA	Crane CA, et al (2013)	I	5/6 patients with increased proliferation	Increased proliferation distinguished immune responders with increased OS