Fig. 6.

Lack of Dgke affects prostanoids synthesis in mouse kidneys. Urinary concentrations of prostaglandins (PG) E₂ (A), PGF₂ (B), and 11-dehydrothromboxane B₂ (11-dh-TxB₂; C) in 24-h urine of Dgke KOs and WT controls in basal conditions and 3 days after PAN injection or Veh as a control, determined by liquid chromatography-electrospray tandem mass spectrometry. Excretion is significantly lower in Dgke KOs compared with controls after PAN treatment. Box and whiskers are 25th and 75th and minimum and maximum, respectively. Lines represent medians; dots correspond to means. Values are means ± SE; n = 4 samples per group. P values were calculated with the Mann-Whitney rank sum t-test. uCr, urinary creatinine.