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Impaired natriuresis in high fat-fed mice. A: cumulative Na+ excretion for the first 24 h on a high-Na+ diet (HSD). B: daily urine Na+ excretion. C: Na+ intake on a normal Na+ diet (NSD) and the first 3 days on a HSD. N = 8 mice/group. *P < 0.05 compared with LFD-fed mice.
