Fig. 8.

A: Representative tracings of a muscle strip from the bladder of a 27-wk-old control rat before and after the addition of α,β-methylene ATP. Note the lack of change in baseline spontaneous activity after the addition of α,β-methylene ATP. B: representative tracings of a muscle strip from the bladder of a 27-wk-old diabetic rat before and after the addition of α,β-methylene ATP. Note the increase in baseline spontaneous activity after the addition of α,β-methylene ATP. C: quantified data analyzed as area under the curve of the spontaneous activity. Spontaneous activity was significantly greater in response to the addition of α,β-methylene ATP in bladders from diabetic animals compared with bladders from control animals; n = 8. *P < 0.05 by Student's t-test.