Fig. 1.

Changes in renal vascular resistance (RVR) in the time domain in response to a step increase in renal perfusion pressure (RPP) before (A) and during inhibition of macula densa-tubuloglomerular feedback (MD-TGF) with mannitol + ureteral obstruction (UO; B) (n = 7 mice). Insets magnify changes in the first 10 s after the RPP increase showing RVR (solid lines) and BP (dashed lines). Changes are shown in admittance gain (C) and phase (D) in the frequency domain during random oscillations in RPP before (solid line) and during inhibition of MD-TGF with mannitol + UO (dashed line) (8 mice). Values are means ± SE (dotted lines).