Table 2.
Diaphragm twitch characteristics and maximum force from 4- and 12-wk-old mice
| 4-wk-old |
12-wk-old |
|||
|---|---|---|---|---|
| Diaphragm | 25 IU/kg | 10,000 IU/kg | 25 IU/kg | 10,000 IU/kg |
| Po, N/cm2 | 14.8 ± 0.98* | 21.6 ± 0.89 | 18.3 ± 0.98 | 19.5 ± 0.98 |
| Pt, N/cm2 | 2.89 ± 0.28 | 3.93 ± 0.14 | 3.28 ± 0.38 | 3.63 ± 0.22 |
| TPT, ms | 24.4 ± 1.27 | 27.5 ± 1.01 | 23.1 ± 0.91 | 25.8 ± 1.71 |
| RT1/2, ms | 55.0 ± 5.0 | 66.3 ± 7.31 | 57.8 ± 4.46 | 53.8 ± 3.80 |
Data are from animals fed diets containing 25 or 10,000 IU/kg of vitamin D for 6 wk. Mice were started on the vitamin D diets beginning at 4 and 12 wk of age (n = 5/group, 20 total). Values are means ± SE. Po, maximal tetanic force; Pt, peak twitch force; TPT, time to peak tension; RT1/2, time it takes for peak tetanic force to decrease by 50%.
Significantly different from 4-wk 10,000 IU/kg (P = 0.001).