Fig. 4.

Ablation of hepatic Plin2 alleviates MCD diet-induced effects on Toll-like receptor 4 (TLR4) and caspase-1. A: Western blot analysis of TLR4, pro-caspase-1, and cleaved caspase-1 levels in hepatic tissue derived from L-KO and WT mice fed the control and MCD diet. B: relative protein expression levels were quantified by densitometric analysis. L-KO mice exhibited decreased levels of pro-caspase-1. The MCD diet increased the ratio of cleaved caspase-1/pro-caspase-1 in WT, an effect that was blunted in similarly fed L-KO mice. Values represent means ± SE, n = 4–5. *P < 0.05 vs. control diet-fed WT mice. @P < 0.05 vs. MCD diet-fed WT mice. #P < 0.05 vs. control diet-fed L-KO mice.