Fig. 3.

Sirt3 knockout (Sirt3.KO) mice do not endure full dose of Doxo treatment and developed exacerbated cardiac hypertrophy and deterioration of cardiac function after treatment. A, top: schematic representation of Doxo treatment protocol to mice. A, bottom: Kaplan-Meier survival analysis of wild-type (WT) and Sirt3.KO mice treated with Doxo. B–D: WT and Sirt3.KO mice were treated with vehicle or Doxo and their heart weight-to-tibia length (HW/TL) ratio (B), LV fractional shortening (C), and SV (D) were determined as described in materials and methods. All values are means ± SE; n = 5–7.