Fig. 3.

High-molecular-weight HA ameliorates inflammatory AHR and remodeling. A and B: in a mouse model of allergic asthma, where mice were exposed to ovalbumin (OVA) + phosphate-buffered saline (PBS), OVA + HA 0.3% solution (Yabro), aluminium adjuvant (ALUM) + PBS, or ALUM + Yabro, HA reduced AHR (A) and reduced proinflammatory cytokines relevant to allergic asthma (B). C: in a model of chronic exposure, HA reduced the expression of specific genes relevant to airway remodeling. IL, interleukin; RL, total lung resistance; MCh, methacholine. *P < 0.05, **P < 0.01, ***P < 0.001.