Table 1.

Roles of endothlin-1-receptor-driven β-arrestin functions in human cancers

Localization	Tumor Type	Interactors	Ref
Cytosolic
β-arr1/β-arr2	Ovarian cancer	C-Src/EGFR	23
β-arr1	Ovarian cancer	PDZ-RhoGEF/RHOA, C GTPase	28
β-arr1	Melanoma	c-Src/VEGFR-3	30
Nuclear
β-arr1	Ovarian cancer	β-Catenin	25, 26
β-arr1	Ovarian cancer	Nuclear factor-κB	7
β-arr1	Ovarian cancer	Angiogenic/metastic genes (Calcrl, Ece1, Foxc1, Icam2, Igfbp1, Igfbp6, Itga5 and Mfng)	33