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. 2016 Feb 10;310(8):R707–R710. doi: 10.1152/ajpregu.00550.2015

Fig. 2.

Fig. 2.

The JAK 1/3 inhibitor R548 significantly reduces messenger RNA levels of the atrogenes atrogin-1 and MuRF1 in cachectic mice. A: messenger RNA expression of the downstream STAT3 transcriptional target SOCS3, and the atrophy-related genes atrogin-1 and MuRF1 in TA muscle of control mice or cachectic C26 mice fed standard chow or chow containing the JAK 1/3 inhibitor R548. Data represent means ± SE; n = 5 or 6 per group. *P < 0.05 vs. control groups. †P < 0.05 vs. C26 mice fed vehicle chow.