Figure 3.

Power from meta-analysis of a population-based random sample and an extreme-selected sample. Power is based on 1000 replicates and 1-SD effect for each rare functional variant. The extreme-selected sample has a sample size of 400 (200 cases and 200 controls) and the population-based random sample has a sample size of 1000. Power is optimal when the population-based random sample has 40% of the weight and the extreme-selected sample has 60% of the weight. This is in contrast to a sample size weighted meta-analysis that would up-weight the random sample.