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RNA pull-down assay for splicing factors bound to the central region of SMN exon 7. (a) Schematic of the synthetic RNA sequences and the pertinent positions in exon 7 of SMN; the underlined base indicates the r.863 g>u(c.863G>T) variant. (b) Western blot analysis. Synthetic RNAs were labeled with biotin and immobilized on agarose beads; proteins were detected with antibodies specific for hnRNP A1, Tra2β1, and SF2/ASF.
