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. 2016 Mar 28;7(5):470–475. doi: 10.1021/acsmedchemlett.5b00483

Figure 3.

Figure 3

Effect of synthesized compounds on BACE-1 activity. The BACE-1 activity was determined as reported in the experimental section in the Supporting Information, in the absence or in the presence of 1 μM synthesized compounds. The residual activity was compared to that exhibited by donepezil (200 nM) or the known Inhibitor I (1 μM) and IV (100 nM) of BACE-1 activity. The data represent the average of at least three determinations and the significance of the data was evaluated by p value (*, < 0.05; **, < 0.005; ***, < 0.0005).