Table 3. Inhibition Parameters of Synthesized Compounds on the Activity of hAChE and BuChE.

	human erythrocytes AChE		horse serum BuChE		selectivity
inhibitor	Ki (μM)	IC50 (μM)	Ki (μM)	IC50 (μM)	from Ki	from IC50
donepezil	0.010 ± 0.006	0.011 ± 0.008	2.140 ± 1.380	1.270 ± 0.410	214	120
13a,b	2.822 ± 0.022	1.540 ± 0.090	10.611 ± 4.205	7.350 ± 0.130	4	5
14	4.224 ± 1.920	1.500 ± 0.23	5.613 ± 1.294	5.800 ± 0.050	1	4
15	0.355 ± 0.035	0.636 ± 0.209	6.480 ± 2.420	4.760 ± 0.041	18	7
16	1.980 ± 0.180	2.160 ± 0.760	8.460 ± 3.930	7.590 ± 0.03	4	4
17	0.035 ± 0.008	0.058 ± 0.033	2.440 ± 1.290	4.740 ± 0.750	71	81
18	0.260 ± 0.036	0.342 ± 0.029	1.140 ± 0.052	2.650 ± 0.617	4	8
19	1.835 ± 0.597	1.509 ± 0.510	3.099 ± 2.610	1.140 ± 0.090	2	1
20	0.029 ± 0.007	0.043 ± 0.007	3.140 ± 1.800	5.734 ± 0.130	110	132
21	0.980 ± 0.220	0.755 ± 0.025	7.254 ± 4.572	15.130 ± 0.025	7	20
22	0.554 ± 0.052	0.853 ± 0.052	3.490 ± 2.240	2.170 ± 1.330	6	3
23	119.490 ± 61.030	34.500 ± 18.470	3.888 ± 3.110	1.620 ± 0.004	<1	<1
24	17.230 ± 6.420	12.155 ± 0.225	2.378 ± 1.730	5.410 ± 0.120	<1	<1
25	39.670 ± 12.040	25.195 ± 21.720	4.328 ± 2.969	9.820 ± 0.200	<1	<1
26	18.200 ± 7.640	11.135 ± 0.054	6.437 ± 2.633	4.820 ± 0.002	<1	<1