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IWP-051 (1, 10, and 30 mg/kg in PEG400) and Bay 41-2272 (10 mg/kg in 0.5% methylcelluolose, Sigma-Aldrich) were dosed orally to male, normotensive Sprague–Dawley rats. Vehicle-subtracted mean arterial pressure (ΔvMAP) in mmHg was monitored for 12–24 h via a conscious, tethered rat model. Data is represented as the change from their own vehicles as 1 h averages + SEM, n = 5–9.
