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Cocrystal structure of 1 bound to the CBP bromodomain (1.6 Å resolution). PDB code: 4YK0. Hydrogen bond interactions between 1, Asn1168, water1, and Tyr1125 are highlighted by dashed lines (distances in Å). The compound makes hydrophobic interactions with Leu1120, Ile1122, and Val1174 (not depicted for clarity). The BRD4 BD-1 binding site differs primarily at residues Leu1109 and Arg1173 (Trp81 and Asp145, respectively, in BRD4 BD-1).
