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Cocrystal structure of 28 in the CBP bromodomain (1.1 Å resolution). PDB code: 5I8G. The benzodiazepinone core recapitulates the key hydrogen bonding interactions observed with the starting fragment, 1, while the 3-pyrazolylindazole substituent improves potency by filling space over Pro1110 and the Pro/Arg cleft.
