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. 2015 Aug 24;35(19):2475–2484. doi: 10.1038/onc.2015.305

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Copyright © 2016 Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/4.0/

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Model describing the effects of MybER-activation on crypt biology and adenoma gene expression as initiating events for CRC. Pink cells identify differentiated goblet cells that are reduced during aberrant crypt focus (ACF) formation following MybER-activation. Further gene expression changes and function consequences are established following progression from ACFs to adenomas.