Table 5.
Performances of BDG (cutoff 80, 100 and 200 pg/mL), CAGTA, MANNAN biomarkers and C-PCR used alone for IC diagnosis
| Invasive candidiasis | Sensitivity % | Specificity % | NPV % | PPV % |
|---|---|---|---|---|
| (95 % CI) | (95 % CI) | (95 % CI) | (95 % CI) | |
| BDG ≥ 80 pg/mL | 76.7 (57.7–90.1) | 57.2 (49.9–64.3) | 94.1 (89.1–96.8) | 21.7 (17.7–26.4) |
| BDG ≥ 100 pg/mL | 70.0 (50.6–85.3) | 61.5 (54.3–68.4) | 93.0 (88.4–95.9) | 21.9 (17.3–27.3) |
| BDG ≥ 200 pg/mL | 60.0 (40.6–77.3) | 79.4 (73.1–84.8) | 92.9 (89.4–95.4) | 30.5 (22.7–39.6) |
| CAGTA positive | 53.3 (34.3–71.7) | 64.3 (57.2–71.0) | 90.1 (86.0–93.2) | 18.4 (13.3–24.8) |
| Mannan-Ag positive | 43.3 (25.5–62.6) | 67.3 (60.3–73.8) | 88.7 (85.0–91.6) | 16.7 (11.3–24.0) |
| Mannan-Ab positive | 25.8 (11.9–44.6) | 89.0 (83.8–93.0) | 88.6 (86.2–90.6) | 26.7 (15.1– 42.6) |
| C-PCR positive | 84.0 (63.9–95.5) | 32.9 (23.1–44.0) | 87.5 (73.1–94.8) | 26.9 (22.7–31.6) |
Values are frequencies and percentages. Biomarker positives: two determinations consecutives positives (≥ cutoff). C-PCR positive: one determination positive
NCI neither colonized nor infected, LGCC low-grade Candida spp. colonization, HGCC high-grade Candida spp. colonization, IAC intra-abdominal candidiasis, BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen; mannan-Ab mannan antibody, C-PCR PCR-based Candida detection