Table 7.
Performances of BDG (cutoff 80, 100 and 200 pg/mL), CAGTA, MANNAN biomarkers and C-PCR used combined for IC diagnosis
| Invasive candidiasis | Sensitivity % | Specificity % | NPV % | PPV % | |
|---|---|---|---|---|---|
| (95 % CI) | (95 % CI) | (95 % CI) | (95 % CI) | ||
| BDG ≥80 pg/mL | CAGTA | 90.3 (74.2–98.0) | 42.1 (35.2–49.2) | 96.6 (90.5–98.8) | 19.3 (16.9–22.0) |
| Mannan-Ag | 80.6 (62.5–92.5) | 44.1 (37.1–51.2) | 93.7 (87.7–96.9) | 18.1 (15.2–21.5) | |
| Mannan-Ab | 74.2 (42.9–57.1) | 50.0 (42.9–57.1) | 92.7 (87.2–95.9) | 18.5 (15.1–22.6) | |
| C-PCR | 76.0 (54.9–90.6) | 40.0 (29.5–51.2) | 85.0 (72.9–92.3) | 27.1 (22.0–33.0) | |
| BDG ≥100 pg/mL | CAGTA | 83.9 (66.3–94.5) | 44.1 (37.1–51.2) | 94.7 (88.7–97.6) | 18.7 (15.9–21.9) |
| Mannan-Ag | 74.2 (55.4–88.1) | 46.5 (39.5–53.7) | 92.2 (86.4–95.6) | 17.6 (14.3–21.4) | |
| Mannan-Ab | 67.7 (48.6–83.3) | 53.5 (46.3–60.5) | 91.5 (86.5–94.8) | 18.3 (14.4–22.9) | |
| C-PCR | 72.0 (50.6–87.9) | 44.7 (33.9–55.9) | 84.4 (73.5–91.4) | 27.7 (21.9–34.3) | |
| BDG ≥200 pg/mL | CAGTA | 77.4 (58.9–96.9) | 55.9 (48.8–62.9) | 94.2 (89.3–96.9) | 21.2 (17.4–25.6) |
| Mannan-Ag | 71.0 (52.0–85.8) | 57.9 (50.8–64.8) | 92.9 (88.1–95.8) | 20.6 (16.4–25.5) | |
| Mannan-Ab | 64.5 (45.4–80.8) | 70.8 (64.0–77.0) | 92.9 (88.9–95.5) | 25.3 (19.5–32.2) | |
| C-PCR | 72.0 (50.6–87.9) | 60.0 (48.8–70.5) | 87.9 (79.1–93.3) | 34.6 (27.0–43.1) | |
| CAGTA positive | Mannan-Ag | 67.7 (48.6–83.3) | 51.0 (43.9–58.1) | 91.2 (85.9–94.6) | 17.5 (13.8–21.9) |
| Mannan-Ab | 64.5 (45.4–80.8) | 57.9 (50.8–64.8) | 91.4 (86.7–94.5) | 19.0 (14.8–24.2) | |
| C-PCR | 56.0 (34.9–75.6) | 55.3 (44.1–66.1) | 81.0 (72.5–87.4) | 26.9 (19.5–35.9) | |
| C-PCR positive | Mannan-Ag | 60.0 (38.7–78.9) | 63.5 (52.4–73.7) | 84.4 (76.5–90.0) | 32.6 (24.0–42.5) |
| Mannan-Ab | 54.8 (36.0–72.7) | 78.7 (72.4–84.1) | 91.9 (88.4–94.4) | 28.3 (20.7–37.5) | |
| Mannan-Ag positive | Mannan-Ab | 54.8 (36.0–72.7) | 59.9 (52.8–66.7) | 89.6 (85.2–92.8) | 17.3 (12.8–23.1) |
Combined biomarkers and C-PCR: two consecutive determinations positive or/and at least one of the biomarkers (in one determination) positive. C-PCR: one determination positive
BDG (1-3)-ß-D-glucan, CAGTA Candida albicans germ tube antibody, mannan-Ag mannan antigen, mannan-Ab mannan antibody, C-PCR PCR-based Candida detection