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. 2016 Feb 28;4(3):344–358. doi: 10.1002/mgg3.208

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© 2016 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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The best‐corrected visual acuity (logMAR equivalent) of affected males' better eye as a function of age (n = 128). The sample population is divided at the critical age (40 years old) into the ≤40 years old group or the >40 years old group. Individuals with missense mutations are indicated by an orange + and labeled; individuals who do not express any Rab escort protein 1 due to whole gene deletions or deletions of the ATG start codon are indicated by a blue ×. The rate of change of visual acuity predicted by a linear regression model (green line) in the ≤40 years old group is not significantly different from 0 (P = 0.71); the rate of change of visual acuity in the >40 years old group is 0.0483 logMAR units/year (P = 0.001).