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. 2016 May 16;6:25971. doi: 10.1038/srep25971

Figure 2. Treatment with rADAMTS 13 in combination with tPA reduced intracerebral thrombosis after MCA occlusion.

Figure 2

(A) Representative immunoblots and quantitative analysis of fibrin in sham-operated mice, and mice treated with vehicle, tPA, tPA in combination with rADAMTS 13, and rADAMTS 13 24 hours after MCA occlusion. The gels have been run under the same experimental conditions. Values are mean ± SD (n = 5 per group). *P < 0.05. (B) Confocal microscopy images of fibrin(green)- and CD31-positive microvessels (red) in the ischemic hemispheres of mice treated with vehicle, tPA, rADAMTS 13 in combination with tPA, and rADAMTS 13 24 hours after MCA occlusion. Bar = 30 μm. Representative pictures from three independent experiments are shown.