Figure 2. Representative images of immunofluorescent labelling of neurons, axons and mitochondrial proteins in passively cleared 250μm mouse cerebellum.
Passively cleared 250 μm wild type mouse cerebellum sections were stained for both neuronal and mitochondrial proteins commonly found in the cerebellum. Calbindin ((a); red; 546 nm) and parvalbumin ((b); purple; 647 nm) antibodies positively label Purkinje cell bodies. Purkinje cell axons were visualised through positive labelling of neurofilaments ((c); red; 546 nm; NF-H, and (d); red; 546 nm; SMI-31) and myelin ((e); purple; 647 nm; MBP). Mitochondria were detected through positive labelling of COXI protein ((f); purple; 647 nm; COXI). Scale bar: 100 μm.
