Table 2. Tissue details for the control subjects and patients with mitochondrial disease that are used in this study.
| Gender | Age (Years) | PMI (Hours) | Formalin-fixed/PFA-sucrose frozen | Fixation (years) | Genetic defect | Cause of Death | Publications | |
|---|---|---|---|---|---|---|---|---|
| Control 1 | F | 72 | 27 | Formalin-fixed | 7 | NA | Pulmonary oedema. | |
| Control 2 | F | 58 | 39 | Formalin-fixed | 8 | NA | Cushing’s disease. | |
| Control 3 | M | 65 | 28 | PFA-sucrose frozen | 15 weeks | NA | Respiratory failure due to acute bronchial asthma. | |
| Patient 1 | M | 30 | 21 | Formalin-fixed | 6 | m.3243 A > G | Left ventricular failure. | 13,14 |
| Patient 2 | M | 58 | 66 | Formalin-fixed | 3 | m.8344 A > G | Stroke-like episode. | 13,14 |
| Patient 3 | M | 79 | 85 | Formalin-fixed | 4 | POLG (p.Thr251Ile/p.Pro587Leu; p.Ala467Thr) | Pneumonia due to mitochondrial disease. | 13,14 |
| Patient 4 | M | 55 | 112 | Formalin-fixed | 3 | POLG (p.Trp748Ser and p.Arg1096Cys) | Complications due to mitochondrial disease. | 13,14 |
| Patient 5 | F | 60 | 39 | Formalin-fixed | 4 | Multiple mtDNA deletions due to an unconfirmed nDNA defect | Pulmonary embolus. | |
| Patient 6 | M | 47 | 76 | Formalin-fixed | 2 | m.3243 A > G | Cardiac arrest. |
The details which include age, gender, Post mortem interval (PMI), fixation length and cause of death from tissue that was supplied by NBTR. NA – Not applicable.