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. 2016 May 16;6:25892. doi: 10.1038/srep25892

Table 2. The differential metabolites among groups.

Metabolites RT_min Mean ± SD Fold Change P value
C SS ADMA SS/C ADMA/C SS vs C ADMA vs SS
HypotaurineLC 3.07 2.060 ± 0.340 1.174 ± 0.157 1.205 ± 0.240 0.570 0.585 0.001 0.815
2,3-Diaminopropionic acidLC 3.40 0.921 ± 0.055 0.684 ± 0.073 0.740 ± 0.083 0.742 0.803 0.000 0.290
Aminoadipic acidLC 3.54 2.209 ± 0.275 1.159 ± 0.161 1.084 ± 0.133 0.525 0.491 0.000 0.443
5-Aminolevulinic acidLC 3.63 0.409 ± 0.125 0.174 ± 0.020 0.169 ± 0.015 0.425 0.412 0.003 0.648
AsparagineLC 3.67 0.990 ± 0.196 0.476 ± 0.060 0.447 ± 0.079 0.481 0.451 0.001 0.524
N-Acetyl-D-glucosamineLC 3.75 0.092 ± 0.006 0.141 ± 0.013 0.148 ± 0.011 1.532 1.613 0.000 0.360
GlutathioneLC 3.97 17.440 ± 2.498 0.281 ± 0.039 0.229 ± 0.131 0.016 0.013 0.000 0.416
DeoxyguanosineLC 4.03 0.756 ± 0.077 1.079 ± 0.253 0.985 ± 0.200 1.427 1.302 0.026 0.531
Pyruvic acidGC 5.37 0.175 ± 0.054 0.091 ± 0.026 0.152 ± 0.041 0.520 0.868 0.014 0.022
3-Hydroxybutyric acidGC 6.93 0.024 ± 0.007 0.044 ± 0.010 0.040 ± 0.010 1.827 1.661 0.007 0.548
UreaGC 8.00 0.009 ± 0.001 0.017 ± 0.002 0.017 ± 0.001 1.835 1.924 0.000 0.406
EthanolamineGC 8.48 0.043 ± 0.010 0.171 ± 0.018 0.189 ± 0.025 4.002 4.418 0.000 0.235
ProlineGC 8.92 1.285 ± 0.439 2.946 ± 0.368 2.691 ± 0.545 2.292 2.094 0.000 0.413
GlycineGC 9.05 1.426 ± 0.389 3.025 ± 0.581 2.765 ± 0.385 2.121 1.939 0.001 0.429
Succinic acidGC 9.06 0.041 ± 0.010 0.027 ± 0.003 0.026 ± 0.003 0.655 0.630 0.014 0.595
Glyceric acidGC 9.39 0.026 ± 0.010 0.062 ± 0.005 0.072 ± 0.004 2.426 2.820 0.000 0.006
UracilGC 9.46 0.060 ± 0.006 0.111 ± 0.022 0.129 ± 0.042 1.837 2.151 0.001 0.403
Fumaric acidGC 9.50 0.124 ± 0.026 0.025 ± 0.004 0.025 ± 0.005 0.202 0.199 0.000 0.927
Aminomalonic acidGC 11.22 0.011 ± 0.007 0.025 ± 0.008 0.023 ± 0.009 2.291 2.095 0.015 0.692
NicotinamideGC 11.23 0.053 ± 0.064 0.164 ± 0.034 0.184 ± 0.045 3.084 3.459 0.009 0.451
Malic acidGC 11.44 0.448 ± 0.090 0.071 ± 0.019 0.062 ± 0.007 0.159 0.139 0.000 0.362
MethionineGC 11.80 0.089 ± 0.024 0.123 ± 0.011 0.122 ± 0.015 1.390 1.370 0.018 0.846
Aspartic acidGC 11.82 1.754 ± 0.454 0.649 ± 0.108 0.616 ± 0.110 0.370 0.351 0.001 0.644
5-oxoprolineGC 11.86 4.664 ± 2.358 1.091 ± 0.107 0.831 ± 0.472 0.234 0.178 0.010 0.264
4-hydroxy-prolineGC 11.91 0.052 ± 0.020 0.004 ± 0.001 0.004 ± 0.001 0.075 0.069 0.001 0.620
Threonic acidGC 12.20 0.024 ± 0.009 0.006 ± 0.001 0.006 ± 0.000 0.244 0.265 0.002 0.271
2-Hydroxyglutaric acidGC 12.47 0.008 ± 0.002 0.004 ± 0.001 0.003 ± 0.000 0.485 0.444 0.004 0.358
GlutamateGC 12.99 1.828 ± 0.522 0.193 ± 0.031 0.187 ± 0.033 0.106 0.102 0.000 0.749
HomocysteineGC 13.51 0.002 ± 0.000 0.009 ± 0.001 0.008 ± 0.002 5.833 5.234 0.000 0.380
XyloseGC 13.81 0.075 ± 0.019 0.208 ± 0.030 0.234 ± 0.019 2.765 3.121 0.000 0.127
ArabinoseGC 14.15 0.002 ± 0.001 0.005 ± 0.002 0.005 ± 0.001 1.990 2.076 0.014 0.815
Glycerol 3-phosphateGC 14.68 0.033 ± 0.006 0.069 ± 0.008 0.069 ± 0.008 2.096 2.096 0.000 0.998
GlutamineGC 14.72 0.867 ± 0.147 0.052 ± 0.018 0.044 ± 0.017 0.060 0.051 0.000 0.470
3-Phosphoglyceric acidGC 15.17 0.006 ± 0.002 0.034 ± 0.012 0.026 ± 0.007 5.861 4.459 0.001 0.223
Myristic acidGC 15.37 0.012 ± 0.002 0.008 ± 0.001 0.009 ± 0.001 0.664 0.709 0.001 0.461
AdenineGC 15.71 0.031 ± 0.008 0.016 ± 0.002 0.016 ± 0.003 0.510 0.505 0.004 0.912
FructoseGC 15.94 0.018 ± 0.003 0.014 ± 0.001 0.018 ± 0.002 0.756 0.999 0.012 0.001
MannoseGC 16.08 0.001 ± 0.000 0.011 ± 0.001 0.011 ± 0.002 7.663 7.346 0.000 0.619
GlucoseGC 16.21 0.016 ± 0.003 0.048 ± 0.006 0.049 ± 0.012 3.017 3.118 0.000 0.793
LysineGC 16.27 0.135 ± 0.032 0.236 ± 0.026 0.238 ± 0.037 1.756 1.766 0.001 0.945
Pentadecanoic acidGC 16.37 0.022 ± 0.002 0.060 ± 0.010 0.067 ± 0.016 2.765 3.103 0.000 0.395
GalactoseGC 16.40 0.002 ± 0.001 0.008 ± 0.001 0.008 ± 0.002 3.365 3.416 0.000 0.909
Glucuronic acidGC 16.63 0.004 ± 0.001 0.013 ± 0.001 0.013 ± 0.002 3.570 3.619 0.000 0.883
Pantothenic acidGC 17.03 0.042 ± 0.011 0.011 ± 0.002 0.012 ± 0.001 0.261 0.275 0.000 0.575
Palmitoleic acidGC 17.20 0.048 ± 0.008 0.108 ± 0.024 0.125 ± 0.036 2.244 2.608 0.001 0.392
RiboseGC 19.10 0.082 ± 0.024 0.033 ± 0.014 0.025 ± 0.016 0.401 0.301 0.004 0.404
Oleic acidGC 19.44 0.059 ± 0.008 0.141 ± 0.021 0.159 ± 0.037 2.401 2.708 0.000 0.376
Glucose 1(6)-phosphateGC 20.99 0.003 ± 0.001 0.020 ± 0.003 0.012 ± 0.001 7.816 4.661 0.000 0.001
Eicosenoic acidGC 21.36 0.004 ± 0.001 0.007 ± 0.001 0.008 ± 0.002 1.833 2.148 0.000 0.166
OrotidineGC 21.45 0.007 ± 0.002 0.026 ± 0.011 0.031 ± 0.007 3.986 4.733 0.004 0.420
Myo-Inositol, phosphateGC 21.71 0.013 ± 0.002 0.026 ± 0.002 0.031 ± 0.004 1.903 2.335 0.000 0.030
5,8,11,14,17-Eicosapentaenoic acidGC 22.41 0.020 ± 0.001 0.027 ± 0.005 0.027 ± 0.005 1.311 1.316 0.017 0.971
Glycerol 1-hexadecanoateGC 22.49 0.060 ± 0.004 0.001 ± 0.000 0.001 ± 0.000 0.023 0.021 0.000 0.441
InosineGC 22.52 0.043 ± 0.013 0.197 ± 0.016 0.191 ± 0.018 4.642 4.487 0.000 0.553
AdenosineGC 22.91 0.020 ± 0.005 0.048 ± 0.014 0.044 ± 0.017 2.420 2.198 0.003 0.664
GuanosineGC 23.87 0.044 ± 0.017 0.098 ± 0.010 0.098 ± 0.026 2.244 2.238 0.000 0.984
CholesterolGC 27.66 2.287 ± 0.295 5.476 ± 0.736 5.715 ± 1.608 2.394 2.499 0.000 0.769

Note: C, SS, and ADMA represent control, 96 h serum starvation and 10 μM ADMA treatment in serum-starved LoVo cells for 96 h, respectively. GC and LC means the data are acquired with GC/TOFMS and LC/TOFMS, respectively.