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. 2016 May 16;6:25918. doi: 10.1038/srep25918

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Copyright © 2016, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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To characterize the function of SOD2 in aiding metastasis, SOD2 siRNA was transfected into SACC-LM cells using Lipofectamine^TM RNAiMAX. Cells were collected and tested 24 h after transfection. SOD2 protein concentrations and activities were significantly lower in the SOD2 siRNA-transfected SACC-LM cells than in the control transfected cells (A,B). SOD2 knockdown inhibited the migration and invasion of SACC-LM cells (C,D). H₂O₂ production was significantly lower in SACC-LM cells after transfection with the SOD2 siRNA (E). CAT protein concentrations and activity in SACC-LM cells did not differ after transfection with SOD2 siRNA (B,F). Vimentin, Slug, Snail, ERK, p-ERK, and MMP-2 protein concentrations were lower in SACC-LM cells but E-cadherin protein concentrations were higher with SOD2 knockdown (B). *P < 0.05.